![]() ![]() when activated, Factor V becomes Factor Va). When a clotting factor becomes activated, it is denoted with an “a” following its respective Roman numeral (e.g. When placed with its glycoprotein co-factor, the clotting factor is activated and is then able to catalyze the next reaction. The clotting factors are initially in an inactive form called zymogens. Each clotting factor is a serine protease, an enzyme that speeds up the breakdown of another protein. This process minimizes blood loss after injuries.The coagulation cascade involves the activation of a series of clotting factors, which are proteins that are involved in blood clotting. Then, the coagulation cascade is activated to stabilize the plug, stopping blood flow and allowing increased time to make necessary repairs. First, primary hemostasis forms an unstable platelet plug at the site of injury. The term hemostasis is derived from “hem-”, which means “blood”, and “-stasis”, which means “to stop.” Therefore, hemostasis means to stop bleeding. The coagulation cascade, or secondary hemostasis, is a series of steps in response to bleeding caused by tissue injury, where each step activates the next and ultimately produces a blood clot. Back Coagulation Cascade What Is It, Steps, and MoreĮditor s : Ahaana Singh, Józia McGowan, DOĬopyeditor : David G. ![]()
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